SERUM ALBUMIN-BINDING FIBRONECTIN TYPE III DOMAINS

The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use...

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Bibliographic Details
Main Authors DAVIS Jonathan, PARKER Rex, LIPOVSEK Dasa, MITCHELL Tracy S, CAMPHAUSEN Ray, FABRIZIO David, GOSSELIN Michael L
Format Patent
LanguageEnglish
Published 22.06.2017
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
Bibliography:Application Number: US201515127166