BETA HAIRPIN PEPTIDES HAVING ANTIVIRAL PROPERTIES AGAINST DENGUE VIRUS

The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these...

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Main Authors REYES ACOSTA Osvaldo, GARATEIX SUÁREZ Rocío, CHINEA SANTIAGO Glay, GONZÁLEZ BLANCO Sonia, PUPO GÓMEZ Dianne, ALVAREZ PÉREZ Karen, MÁRQUEZ PERERA Gabriel Jesús, GUIROLA CRUZ Osmany, VÁZQUEZ CASTILLO Mariela, GARAY PÉREZ Hilda Elisa, MARTÍN DUNN Alejandro Miguel, HUERTA GALINDO Vivian, FALCÓN CAMA Viviana, GONZÁLEZ LÓPEZ Luis Javier, SARRÍA NÚÑEZ Mónica, YERO DÍAZ Alexis
Format Patent
LanguageEnglish
Published 01.06.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.
Bibliography:Application Number: US201515119058