TRANS-ACTING ELEMENTS FOR INTRACELLULAR DELIVERY OF NUCLEIC ACID SEQUENCES

The invention concerns compounds of the formula (Z)x wherein: each Z is independently selected from 2'-deoxythymidinyl moiety, 2'-deoxyadenosinyl moiety, and a 2'-deoxycytidinyl moiety, x is an integer from 5 - 20, wherein said 2'-deoxythymidinyl moieties are connected by thiopho...

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Bibliographic Details
Main Authors JAIN Harsh V, BEAUCAGE Serge L
Format Patent
LanguageEnglish
Published 11.05.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:The invention concerns compounds of the formula (Z)x wherein: each Z is independently selected from 2'-deoxythymidinyl moiety, 2'-deoxyadenosinyl moiety, and a 2'-deoxycytidinyl moiety, x is an integer from 5 - 20, wherein said 2'-deoxythymidinyl moieties are connected by thiophosphate triester linkages, 3-12 of said thiophosphate triester linkages being positively charged linkages of the formula (I) where n is an integer from 2 to 6; the remainder of said thiophosphate triester linkages are neutral linkages of the formula (II) provided that when x is 5-6, the number of positively charged linkages is 3, when x is 7-8, the number of positively charged linkages is 3-4, when x is 9-12, the number of positively charged linkages is 3-10, when x is 13-20, the number of positively charged linkages is 4-12.
Bibliography:Application Number: US201615265436