FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibi...

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Main Authors Gao Ying-Duo, Jiang Yu, Sha Deyou, Kumar Puneet, Hussain Zahid, Neelamkavil Santhosh F, Chakrabarti Anjan, Liu Weiguo, Lim Yeon-Hee, Gallo-Etienne Giocanda V, Xu Jiayi, Yu Younong, Moningka Remond, Sone Hiroki, Guo Zhuyan, Stamford Andrew W, Kevin Nancy J, Duffy Joseph L, Ali Amjad, Edmondson Scott D, Wu Heping, Anand Rajan
Format Patent
LanguageEnglish
Published 16.02.2017
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Bibliography:Application Number: US201515305421