SINGLE CHAIN IL-12 NUCLEIC ACIDS, POLYPEPTIDES, AND USES THEREOF

The present invention relates to novel single chain interleukin-12 polypeptides. The invention also relates to isolated nucleic acids encoding the single chain interleukin-12 polypeptides, to vectors and cells comprising them, and to their uses, in particular in methods of using single chain IL-12 p...

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Bibliographic Details
Main Authors ZHANG Chi, SOPCZYNSKI Joan Mazzarelli
Format Patent
LanguageEnglish
Published 27.10.2016
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to novel single chain interleukin-12 polypeptides. The invention also relates to isolated nucleic acids encoding the single chain interleukin-12 polypeptides, to vectors and cells comprising them, and to their uses, in particular in methods of using single chain IL-12 polypeptides, polynucleotides, vectors and cells of the invention for enhancing immune system function, for example as vaccine adjuvants and in the treatment of infections and cancer.
Bibliography:Application Number: US201415105435