METHOD AND SYSTEM FOR PREDICTING SELECTIVE CANCER DRUG TARGETS

A method for creating a metabolic map of metabolic reactions by selecting metabolic reactions active in cancer cells. A core set of metabolic reactions occurring in the cancer cells is designated. For each permutation, whether inhibition of the k-th non-core reaction together with inhibition of all...

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Bibliographic Details
Main Authors SHLOMI Tomer, FOLGER Ori, Ruppin Eytan, GOTTLIEB Eyal, FREZZA Christian
Format Patent
LanguageEnglish
Published 13.10.2016
Subjects
CALCULATING
COMPUTING
COUNTING
ELECTRIC DIGITAL DATA PROCESSING
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
PHYSICS
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Summary:A method for creating a metabolic map of metabolic reactions by selecting metabolic reactions active in cancer cells. A core set of metabolic reactions occurring in the cancer cells is designated. For each permutation, whether inhibition of the k-th non-core reaction together with inhibition of all previously deleted non-core reactions results in inhibition of any of the core reactions or results in inhibition of the flux of biomass metabolites to biomass is determined. If inhibition of the k-th non-core reaction and inhibition of all previously deleted non-core reactions does not result in inhibition of any core reactions and does not result in inhibition of the flux of biomass metabolites to biomass, then the k-th non-core reaction is deleted from the set of non-core reactions. The number of permutations for which the k-th non-core reaction is not deleted is determined and a metabolic map is then created based on that number.
Bibliography:Application Number: US201615086672