Fused Imidazole and Pyrazole Derivatives As Modulators of TNF Activity

A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory...

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Main Authors Chovatia Praful Tulshi, Selby Matthew Duncan, Lecomte Fabien Claude, Miller Craig, Porter John Robert, Brace Gareth Neil, Vaidya Darshan Gunvant, Alexander Rikki Peter, Brookings Daniel Christopher, Kroeplien Boris, Johnstone Craig, Bentley Jonathan Mark, Jones Elizabeth Pearl, Madden James, Shaw Michael Alan, Yule Ian Andrew, Deboves Hervé Jean Claude
Format Patent
LanguageEnglish
Published 13.10.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Bibliography:Application Number: US201415100825