NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF

Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting o...

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Bibliographic Details
Main Authors MONLISH Darlene, ELLIOTT Steven, CAVANAUGH Jane E, FLAHERTY Patrick T, HOANG Van T, CHAKRABARTY Suravi, BUROW Mattthew E
Format Patent
LanguageEnglish
Published 04.08.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.
Bibliography:Application Number: US201415021592