ANTIBODIES WITH ENHANCED OR SUPPRESSED EFFECTOR FUNCTION

Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when i...

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Bibliographic Details
Main Authors TOM-YEW STACEY A.L, ESCOBAR-CABRERA ERIC, OHRN ANDERS, D'ANGELO IGOR, DIXIT SURJIT B, LARIO PAULA I, POON DAVID K.Y, BLEILE DUSTIN
Format Patent
LanguageEnglish
Published 09.06.2016
Subjects
CHEMISTRY
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
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Summary:Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
Bibliography:Application Number: US201615046379