MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

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Bibliographic Details
Main Authors MULL ERIC, ZHU JULIANG, BOY KENNETH M, SCOLA PAUL MICHAEL, YEUNG KAP-SUN, BOWSHER MICHAEL S, SANGHVI NISHITH, REID PATRICK C, SUN LI-QIANG, MILLER MICHAEL MATTHEW, TENNEY DANIEL J, POIRIER MAUDE A, GILLIS ERIC P, LANGLEY DAVID R, MAPELLI CLAUDIO, ALLEN MARTIN PATRICK
Format Patent
LanguageEnglish
Published 09.06.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Bibliography:Application Number: US201615009575