USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS

A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a -lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics suc...

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Bibliographic Details
Main Authors ROUSSEL PATRICK, GAUCHER BÉRANGÈRE, PAGE MALCOM G.P, DESARBRE ERIC
Format Patent
LanguageEnglish
Published 05.05.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a -lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another -lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).
Bibliography:Application Number: US201614993747