Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

• Main Authors: BINCH HAYLEY MARIE, MCCARTNEY JASON, JOSHI PRAMOD VIRUPAX, PIERRE FABRICE JEAN DENIS, UY JOHNNY, SILINA ALINA, ARUMUGAM VIJAYALAKSMI, GROSS RAYMOND STANLEY, KRENITSKY PAUL JOHN, CONROY ERICA, COON TIMOTHY RICHARD, FRIEMAN BRYAN A, TERMIN ANDREAS P, NICHOLLS GEORGIA MCGAUGHEY, ZHOU JINGLAN, GROOTENHUIS PETER DIEDERIK JAN, LIN CHUNIEH, HADIDA-RUAH SARA SABINA, ANDERSON COREY, MELILLO VITO, CLEVELAND THOMAS, BEAR BRIAN RICHARD, MILLER MARK THOMAS, HARIPADA KHATUYA, MARELIUS GULIN ERDGOGAN, CLEMENS JEREMY J
• Format: Patent
• Language: English
• Published: 07.04.2016
• Subjects: BABY COMFORTERS; CHEMISTRY; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR RECEIVING SPITTLE; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.