NOVEL CHROMONE ALKALOID DYSOLINE FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISORDERS

The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant Dysoxylum binectariferum. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits p...

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Main Authors JAIN SHREYANS KUMAR, UMA SHAANKER RAMANAN, VISHWAKARMA RAM ASREY, GANESHAIAH KOTIGANAHALLI NARAYANAGOWDA, BHOLA SUNIL KUMAR, SIDI TABASUM, VASUDEVA RAMESH, QAZI ASIF KHURSHID, RAVIKANTH GUDASALAMANI, MEENA SAMDARSHI, KHAJURIA ANAMIKA, DAR ABID HAMID, HUSSAIN AASHIQ, MOHANA KUMARA PATEL, BHARATE SANDIP BIBISHAN
Format Patent
LanguageEnglish
Published 18.02.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant Dysoxylum binectariferum. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits production of pro-inflammatory cytokines. The formulations of this particular compound can be used for treatment of cancer and inflammation.
Bibliography:Application Number: US201414783878