MONOCLONAL ANTIBODY FOR ANTAGONIZING AND INHIBITING BINDING OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR AND ITS RECEPTOR, AND CODING SEQUENCE AND USE THEREOF

A mouse monoclonal antibody for antagonizing and inhibiting binding of a vascular endothelial cell growth factor (VEGF) and its receptor (VEGF-R), and a heavy chain variable region and light chain variable region amino acid sequence thereof. Also disclosed are a humanized preparation process of the...

Full description

Saved in:
Bibliographic Details
Main Authors SHI DONGHONG, HU HONGQUN, LUO SHIPING, SUN YANAN, PING XIAOYA, ZHOU JIANYING, LIU HAIYUN, CAI MINGWEN, ZHOU QUNMIN, SONG XIAOQI, XU YIQING, CHEN SIYU, CHEN ZUI
Format Patent
LanguageEnglish
Published 11.02.2016
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online AccessGet full text

Cover

More Information
Summary:A mouse monoclonal antibody for antagonizing and inhibiting binding of a vascular endothelial cell growth factor (VEGF) and its receptor (VEGF-R), and a heavy chain variable region and light chain variable region amino acid sequence thereof. Also disclosed are a humanized preparation process of the antibody and a heavy chain variable region and light chain variable region amino acid sequence of the humanized antibody. The humanized antibody or its derivative can act as an ingredient of a pharmaceutical composition or be prepared into a suitable pharmaceutical preparation, is administered alone or in combination with a chemotherapy drug or other treatment means, and is used in broad-spectrum treatment of various solid tumors such as colon cancer, breast cancer and rhabdomyosarcoma.
Bibliography:Application Number: US201314651785