COMPOSITIONS AND METHODS FOR ENHANCING THE THERAPEUTIC POTENTIAL OF STEM CELLS

The invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease, The methods involve-administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (MSCs) and a non-mu...

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Bibliographic Details
Main Authors REINISCH BARBARA, SCHENK JUDITH, ROSENBAUM CLAUDIA, VAN DEN BOS CHRISTIAN
Format Patent
LanguageEnglish
Published 04.02.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease, The methods involve-administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (MSCs) and a non-muscle myosin 0 antagonist such as blebbistatin. Non-muscle myosin II antagonists are disclosed to surprisingly and dramatically accelerate MSC-triggered regeneration of damaged tissues arid unexpectedly and drastically reduce severe complications of stem cell treatment.
Bibliography:Application Number: US201414777352