METHOD FOR DISCRIMINATING BETWEEN MALIGNANT AND BENIGN TISSUE LESIONS

• Main Authors: NIELSEN KRISTIAN P, SOMMERSTEN ENDRE R, STAMNES KNUT, HAMRE BOERGE, MOAN JOHAN E, RYZHIKOV GENNADY, ZHAO LU, BURYULINA MARINA, STAMNES JAKOB J
• Format: Patent
• Language: English
• Published: 22.10.2015
• Subjects: CALCULATING; COMPUTING; COUNTING; DIAGNOSIS; ELECTRIC DIGITAL DATA PROCESSING; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; IMAGE DATA PROCESSING OR GENERATION, IN GENERAL; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEDICAL OR VETERINARY SCIENCE; PHYSICS; SURGERY

An embodiment of the present invention includes a method for discriminating between benign and malignant tissue lesions. The method includes the steps of using a plurality of maps of physiology and morphology parameters generated from reflectance measurements and morphology parameters generated from reflectance measurements. The method also includes calculating entropies and cross entropies of the plurality of maps, and calculating a plurality of morphology parameters. Further, the method includes assigning a weight to each entropy and a weight to a logarithm of each entropy, a weight to each cross entropy and a weight to a logarithm of each cross entropy, and a weight to each morphology parameter and a weight to a logarithm of each morphology parameter. The method further includes computing a diagnostic index, defining a cost function, defining a proper threshold value for a diagnostic index and solving an optimization problem to determine a set of weights from the assigned weights to maximize specificity for 100% sensitivity. Further, the method uses calculations, the cost function and the diagnostic index to determine whether the tissue lesion is benign or malignant.