NOVEL BENZOAZEPINE DERIVATIVE AND MEDICAL USE THEREOF

• Main Authors: ASANO YUKIYASU, KITAMOTO KATSUNORI, KUNO YUKA, GOTOH IZUMI, KURUMAZUKA DAISUKE, KATAOKA HIROYO, TAKEUCHI MITSUAKI, KASUGAI NOBUYOSHI, YAMADA YURIE, OHSAWA YASUSHI, HARADA SATOKO, TAKAHASHI NAOKI, OKABE MORIO, FUJIEDA HIROKI, IZUCHI TORU, SAKAI KEITA, MIYAZAWA TOSHIYUKI, NAGANO HIROKI
• Format: Patent
• Language: English
• Published: 15.10.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

A compound having a V2 receptor agonistic activity is provided. Providing a pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) described below: [R1 is formula described below: (A is a lower alkylene group which may be substituted with lower alkyl group; R6 is a hydrogen atom; R7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with lower alkyl group, carbamoyl group); R2 is a hydrogen atom or lower alkyl group; R3 is lower alkyl group which may be substituted with 1-3 fluorine atoms, or halogen atom; R4 is a five-membered aromatic monocyclic heterocyclic group, five-membered non-aromatic monocyclic heterocyclic group, (provided each heterocyclic groups contain at least one nitrogen atom and may be substituted with a lower alkyl group); and R5 is a lower alkyl group, halogen atom], or pharmacologically acceptable salt thereof.