FUSED HETEROCYCLIC DERIVATIVES AS S1P MODULATORS

The present invention relates to a fused heterocyclic derivative of the formula (I) The variables R1-R4, z, A, Q, X and Y are as defined in the claims. The following heterocycles are exemplified sub-structures of formula (I): The compounds of formula (I) are modulators of the S1P receptor (Sphingosi...

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Main Authors SMID PIETER, SLIEDREGT LEONARDUS A.J.M, VAN DONGEN MARIA J.P, DEN HARTOG JACOBUS A.J, HOBSON ADRIAN, COOLEN HEIN K.A.C, IWEMA BAKKER WOUTER I
Format Patent
LanguageEnglish
Published 08.10.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a fused heterocyclic derivative of the formula (I) The variables R1-R4, z, A, Q, X and Y are as defined in the claims. The following heterocycles are exemplified sub-structures of formula (I): The compounds of formula (I) are modulators of the S1P receptor (Sphingosine-1-phosphate receptor), More specifically, they are agonists of S1P5. The compounds have therapeutic use in treatment of cognitive disorders, age-relate cognitive decline and dementia.
Bibliography:Application Number: US201514743234