Method for Measuring ATR Inhibition Mediated Increases in DNA Damage

The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging age...

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Bibliographic Details
Main Authors REAPER PHILIP, MIDDLETON FIONA, CHEN TAO, CURTIN NICOLA, POLLARD JOHN, FALCON SUSANNA
Format Patent
LanguageEnglish
Published 03.09.2015
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX and/or pChk1Ser345 in, e.g., surrogate tissue cells, following ex vivo stimulation with a DNA damaging agent.
Bibliography:Application Number: US201514633394