N-CARBOXYALKYL-AURISTATIN AND USE THEREOF

The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of d...

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Main Authors STELET-LUDWIG BEATRIX, GOLFIER SVEN, SCHUHMACHER JOACHIM, LERCHEN HANS-GEORG, GNOTH JEAN MARK, EL SHEIKH SHERIF, KRENZ URSULA
Format Patent
LanguageEnglish
Published 28.05.2015
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.
Bibliography:Application Number: US201514615005