NITRIC OXIDE RELEASING STEROIDS

The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof R-(Z)a-Rx  (I) wherein R is the corticosteroid residue of formula (II): wherein: R1 is OH, R2 -CH3, or R1 and R2 are taken together to form a group of...

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Bibliographic Details
Main Authors BENEDINI FRANCESCA, ONGINI ENNIO, BIONDI STEFANO
Format Patent
LanguageEnglish
Published 16.04.2015
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof R-(Z)a-Rx  (I) wherein R is the corticosteroid residue of formula (II): wherein: R1 is OH, R2 -CH3, or R1 and R2 are taken together to form a group of formula (III) R3 is Cl or F; R4 is H or F; wherein R1, R2, R3 and R4 can be linked to the correspondent carbon atoms of the steroidal structure in position α or ; with the proviso that: when R1 and R2 are the group of formula (III) then R3 is F and R4 is H or F; The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and ocular diseases.
Bibliography:Application Number: US201414554830