Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors

The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.

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Main Authors GADDAM BAPU, KOSTURA MATTHEW J, GUZEL MUSTAFA, MJALLI ADNAN M.M, POLISETTI DHARMA RAO
Format Patent
LanguageEnglish
Published 18.12.2014
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Abstract The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
AbstractList The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
Author GADDAM BAPU
POLISETTI DHARMA RAO
GUZEL MUSTAFA
MJALLI ADNAN M.M
KOSTURA MATTHEW J
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Snippet The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of...
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HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors
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