IL-17 RECEPTOR A IS REQUIRED FOR IL-17C BIOLOGY

The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor E form a heteromeric receptor complex that is biologically active, and that IL-17C activity requires the IL-17RA-IL-17RE heteromeric receptor complex. Antagon...

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Bibliographic Details
Main Authors BUDELSKY ALISON L, SYMONS ANTONY, SIEGEL LORI, ZHANG YU, TOWNE JENNIFER E
Format Patent
LanguageEnglish
Published 21.08.2014
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor E form a heteromeric receptor complex that is biologically active, and that IL-17C activity requires the IL-17RA-IL-17RE heteromeric receptor complex. Antagonists of the IL-17RA-IL-17RE heteromeric receptor complex are disclosed, as well as various methods of use.
Bibliography:Application Number: US201214234064