IL-17 RECEPTOR A IS REQUIRED FOR IL-17C BIOLOGY
The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor E form a heteromeric receptor complex that is biologically active, and that IL-17C activity requires the IL-17RA-IL-17RE heteromeric receptor complex. Antagon...
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Main Authors | , , , , |
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Format | Patent |
Language | English |
Published |
21.08.2014
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor E form a heteromeric receptor complex that is biologically active, and that IL-17C activity requires the IL-17RA-IL-17RE heteromeric receptor complex. Antagonists of the IL-17RA-IL-17RE heteromeric receptor complex are disclosed, as well as various methods of use. |
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Bibliography: | Application Number: US201214234064 |