5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES

Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory...

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Main Authors MORENO DAVID A, SCHLACHTER STEPHEN T, HARVEY DARREN, BOYS MARK LAURENCE, GRONEBERG ROBERT, KRASER CHRISTOPHER F, HACHE BRUNO P, HICKEN ERIK JAMES, ROBINSON JOHN E, REN LI, LAIRD ELLEN, MUNSON MARK C, BURGESS LAURENCE E, EARY C. TODD
Format Patent
LanguageEnglish
Published 14.08.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
Bibliography:Application Number: US201214351415