BINDING MEMBERS-513

This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by K...

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Main Authors LOWE DAVID CHRISTOPHER, CAMPBELL JAMIE IAIN, COCHRANE DUNCAN JAMES, FINCH DONNA KIRSTY, GROVES MARIA ANASTASIA TERESA, CRUWYS SIMON CHARLES
Format Patent
LanguageEnglish
Published 31.07.2014
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).
Bibliography:Application Number: US201414253954