Process for Forming Amorphous Atorvastatin

A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxida...

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Bibliographic Details
Main Authors ROSE PETER ROBERT, SHALAEV EVGENYI, QUALLICH GEORGE JOSEPH, DEBETTENCOURT, III ANTONE JOHN, ZIEGLER CARL BERNARD
Format Patent
LanguageEnglish
Published 05.06.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
Bibliography:Application Number: US201414176081