MONOCLONAL ANTIBODIES SPECIFIC FOR BETA-AMYLOID X-37 AND USES THEREOF

The present invention provides monoclonal antibodies which specifically recognize the shorter A peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the A -peptide fragments A 1-37, A 3-37, A 3p-37, A 1-37 and A 11p-37, and other like fragments ending at the 37th amino a...

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Bibliographic Details
Main Authors MERCKEN MARC HUBERT, BORGERS MARIANNE, VANDERMEEREN MARC, MARIA, PIERRE, PELAGIE, VAN BROECK BIANCA JULIA J
Format Patent
LanguageEnglish
Published 05.06.2014
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The present invention provides monoclonal antibodies which specifically recognize the shorter A peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the A -peptide fragments A 1-37, A 3-37, A 3p-37, A 1-37 and A 11p-37, and other like fragments ending at the 37th amino acid of APP, hereinafter also referred to as the A x-37 peptides. It further provides hybridoma cells producing the monoclonal antibodies as well as methods for producing the antibodies and the hybridoma cells; and an immunoassay for an A x-37 peptide by a competitive method or a sandwich method using the antibody of the present invention; and methods for measuring the level of A x-37 peptides in a sample, such as a biological sample.
Bibliography:Application Number: US201214233068