ALPHA5-BETA1 ANTIBODIES AND THEIR USES

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5 1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells...

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Main Authors WANG JIANYING, CHEN HAIBIN, WICKMAN GRANT, TANAMACHI DAWN M, YANG LAN, JIANG XIN, BRAMS PETER, BENDER STEVEN LEE, DEVAUX BRIGITTE, TOY KRISTOPHER, SPROUL TIM W, HU-LOWE DANA DAN, CASPERSON GERALD FRIES, YAMANAKA MARK, NORTH MICHAEL AIDAN, HUANG HAICHUN, LI GANG
Format Patent
LanguageEnglish
Published 05.06.2014
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5 1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5 1 antibodies or antigen binding portions thereof described herein.
Bibliography:Application Number: US201313772992