METHOD FOR DETECTION OF AMYLOIDS BETA OLIGOMERS IN A FLUID SAMPLE AND USES THEREOF

The invention herein is directed to a selective A oligomer immunoassay capable of reliably and sensitively detecting A oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-A oligomer antibodies, 19.3 and 82E1, to detect and quantify A oligomers in...

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Bibliographic Details
Main Authors SHUGHRUE PAUL J, MCCAMPBELL ALEXANDER, SAVAGE MARY J, WOLFE ABIGAIL L
Format Patent
LanguageEnglish
Published 01.05.2014
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The invention herein is directed to a selective A oligomer immunoassay capable of reliably and sensitively detecting A oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-A oligomer antibodies, 19.3 and 82E1, to detect and quantify A oligomers in a cerebrospinal fluid (CSF) sample. The inventive assay can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease. The inventive assay can also be used as a target engagement assay that can measure bound A oligomers as a surrogate end-point for the assessment of therapeutic efficacy and/or target engagement.
Bibliography:Application Number: US201314137351