PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor...

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Main Authors HUANG XIN, LIU JIWEN, EKSTERWICZ JOHN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GRIBBLE MICHAEL WILLIAM, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, GUSTIN DANN JAMES, BARTBERGER MICHAEL DAVID, MCGEE LAWRENCE R, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Format Patent
LanguageEnglish
Published 09.01.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
Bibliography:Application Number: US201314025688