ALDOSTERONE SYNTHASE INHIBITORS

The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldos...

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Main Authors CAI JAIQIANG, HOYT SCOTT B, CARSWELL EMMA, MACLEAN JOHN, LONDON CLARE, KULKARNI BHEEMASHANKAR A, GUPTA ARCHANA, PARK MIN K, COOKE ANDREW, XIONG YUSHENG, BENNETT D. JONATHAN, RATCLIFFE PAUL, SAXENA ROHIT
Format Patent
LanguageEnglish
Published 28.11.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.
Bibliography:Application Number: US201113811059