COMPOUNDS AND METHODS FOR PKC THETA INHIBITION

The present invention provides a method of selectively inhibiting PKCtheta in the presence of PKCdelta, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T c...

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Bibliographic Details
Main Authors MEYER RICH B, HUMMEL HEIDI S, AJIOKA JANET, SWINDLE JOHN
Format Patent
LanguageEnglish
Published 29.08.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a method of selectively inhibiting PKCtheta in the presence of PKCdelta, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.
Bibliography:Application Number: US201313861646