MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS

Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseas...

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Main Authors JIANG YUTONG, KOLAKOWSKI GABRIELLE R, CONDROSKI KEVIN RONALD, HAAS JULIA, SEO JEONGBEOB, ZHAO QIAN, ANDREWS STEVEN WADE, YANG HONGWOON
Format Patent
LanguageEnglish
Published 08.08.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Bibliography:Application Number: US201113698922