BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT

The present invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persi...

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Main Authors RIND HOWARD B, DOLBY LLOYD JAY, CHAO ELLEN, TON HAU, GARST MICHAEL S, HANSEN MARK R, EHRING GEORGE R, ADORANTE JOSEPH S, AVEY ALFRED ARTHUR, ESFANDIARI SHERVIN, MUCHMORE DAVID CHARLES, MACKENZIE VIVIAN R, MARSDEN JEREMIAH ANDREW, LI JIA CHIAN, NG HERMAN
Format Patent
LanguageEnglish
Published 04.07.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is directed to a compound of Formula I or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.
Bibliography:Application Number: US201213727860