Process for the Production of Seven-Membered Lactam Morphinans

The present invention relates to improved processes for preparing lactam morphinans. The processes generally transform keto-morphinans to seven-membered lactam morphinans using a hydroxyamine sulfonic acid reagent and proceed in high yield and with good selectivity.

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Bibliographic Details
Main Authors MOSER FRANK W, MCCLURG JOSEPH P, GROTE CHRISTOPHER W
Format Patent
LanguageEnglish
Published 06.06.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to improved processes for preparing lactam morphinans. The processes generally transform keto-morphinans to seven-membered lactam morphinans using a hydroxyamine sulfonic acid reagent and proceed in high yield and with good selectivity.
Bibliography:Application Number: US201213705205