Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating...

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Main Authors GRUDZINSKA JOANNA, SCHOLZ PETER, BIRKENFELD JOERG, STEINIG SUSANNE, BRUECKNER SIMONE, WANG ZHUOZHI, PAN JUNLIANG, VOTSMEIER CHRISTIAN, TEBBE JAN, WOBST NINA
Format Patent
LanguageEnglish
Published 27.12.2012
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.
Bibliography:Application Number: US201113582401