PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS

The present invention provides Pyrazolopyrimidine Compounds of Formula (I): wherein L, T, Z, U, V, W, R3, R6, R7, R8, and m are as defined herein, and pharmaceutically acceptable salts of such Pyrazolopyrimidine Compounds. The Pyrazolopyrimidine Compounds are useful in the treatment of cancer and ot...

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Main Authors VITHARANA LALANTHI DILRUKSHI, PATEL MEHUL F, LIU DUAN, CURRAN PATRICK J, NAN YANG, MCRINER ANDREW, MANSOOR UMAR FARUK, REDDY PANDURANGA ADULLA P, TANG SHUYI, BELANGER DAVID B, ZHAO LIANYUN, MANDAL AMIT K, DAI CHAOYANG, MENG ZHAOYANG, SIDDIQUI M. ARSHAD, DANIELS MATTHEW HERSH, ANGELES ANGIE R, YANG LIPING
Format Patent
LanguageEnglish
Published 20.12.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides Pyrazolopyrimidine Compounds of Formula (I): wherein L, T, Z, U, V, W, R3, R6, R7, R8, and m are as defined herein, and pharmaceutically acceptable salts of such Pyrazolopyrimidine Compounds. The Pyrazolopyrimidine Compounds are useful in the treatment of cancer and other diseases or disorders wherein mTOR is deregulated.
Bibliography:Application Number: US201113520274