ASYNTHESIS OF B-NUCLEOSIDES

A process of stereoselectively synthesizing -nucleoside, e.g., 2′-deoxy-2,2′-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula: in which wherein R1, R2, R3, R4, and L as defined in the specification, with a nucleobase derivative in the...

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Bibliographic Details
Main Authors CHIEN CHUNGSUN, CHIEN PIN-SHU, HWANG CHAN-KOU
Format Patent
LanguageEnglish
Published 11.10.2012
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:A process of stereoselectively synthesizing -nucleoside, e.g., 2′-deoxy-2,2′-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula: in which wherein R1, R2, R3, R4, and L as defined in the specification, with a nucleobase derivative in the presence of an oxidizing agent.
Bibliography:Application Number: US201213435607