COMPOSITIONS CONTAINING GLYCOSYLATED ANTIBODIES AND USES THEREOF

The present invention provides compositions of antibodies, e.g., human antibodies, of varying glycosylation structures that serve to achieve desired rates of serum clearance. The invention also provides methods for modulating the pharmacokinetics of antibodies, e.g., human antibodies, and therapeuti...

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Bibliographic Details
Main Authors FUJIMORI TARO, CORREIA IVAN R.S, HRUSKA MATTHEW W, PAULSON SUSAN KAYE
Format Patent
LanguageEnglish
Published 02.08.2012
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides compositions of antibodies, e.g., human antibodies, of varying glycosylation structures that serve to achieve desired rates of serum clearance. The invention also provides methods for modulating the pharmacokinetics of antibodies, e.g., human antibodies, and therapeutic compositions containing such antibodies. These methods rely on varying the glycosylation structures of the antibodies, e.g., human antibodies, to achieve desired rates of serum clearance.
Bibliography:Application Number: US201213359250