Method of Modification of Hyaluronic Acid by Means of (O-ACYL-O'-ALKYL Carbonate-Substituted Pyridine) Complex
This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O′-alkyl carbonate-substituted pyridine) of the general formula R-CO-O-CO-O-R1 and R25C5N. The reaction takes place in DMSO in the presence of...
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Format | Patent |
Language | English |
Published |
19.04.2012
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Abstract | This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O′-alkyl carbonate-substituted pyridine) of the general formula R-CO-O-CO-O-R1 and R25C5N. The reaction takes place in DMSO in the presence of an external base, forming O-acylated products. The method leads to higher substitution degrees and shorter reaction times compared to the known analogues, hi case the agent comprises two or more functional groups R(CO-O-CO-O-R1)n, crosslinked hyaluronic acid derivatives are formed. |
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AbstractList | This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O′-alkyl carbonate-substituted pyridine) of the general formula R-CO-O-CO-O-R1 and R25C5N. The reaction takes place in DMSO in the presence of an external base, forming O-acylated products. The method leads to higher substitution degrees and shorter reaction times compared to the known analogues, hi case the agent comprises two or more functional groups R(CO-O-CO-O-R1)n, crosslinked hyaluronic acid derivatives are formed. |
Author | PRAVDA MARTIN NIKODYM PAVEL PALEK LUKAS BUFFA RADOVAN PRIKOPOVA EVA POSPISILOVA LUCIE VELEBNY VLADIMIR |
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Snippet | This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex... |
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Title | Method of Modification of Hyaluronic Acid by Means of (O-ACYL-O'-ALKYL Carbonate-Substituted Pyridine) Complex |
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