Method of Modification of Hyaluronic Acid by Means of (O-ACYL-O'-ALKYL Carbonate-Substituted Pyridine) Complex

This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O′-alkyl carbonate-substituted pyridine) of the general formula R-CO-O-CO-O-R1 and R25C5N. The reaction takes place in DMSO in the presence of...

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Bibliographic Details
Main Authors NIKODYM PAVEL, PRAVDA MARTIN, VELEBNY VLADIMIR, POSPISILOVA LUCIE, BUFFA RADOVAN, PALEK LUKAS, PRIKOPOVA EVA
Format Patent
LanguageEnglish
Published 19.04.2012
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O′-alkyl carbonate-substituted pyridine) of the general formula R-CO-O-CO-O-R1 and R25C5N. The reaction takes place in DMSO in the presence of an external base, forming O-acylated products. The method leads to higher substitution degrees and shorter reaction times compared to the known analogues, hi case the agent comprises two or more functional groups R(CO-O-CO-O-R1)n, crosslinked hyaluronic acid derivatives are formed.
Bibliography:Application Number: US201013256966