pH Sensitive Metal Nanoparticle and Preparation Method

• Main Authors: CHUNG HYO KYUN, JEONG SANG HWA, NAM JU TAEK, KIM SUNG JEE, WONYOUN
• Format: Patent
• Language: English
• Published: 03.11.2011
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CASTING; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; GAMMA RAY OR X-RAY MICROSCOPES; HAIRDRESSING OR SHAVING EQUIPMENT; HAND OR TRAVELLING ARTICLES; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; IRRADIATION DEVICES; MAKING METALLIC POWDER; MANICURING OR OTHER COSMETIC TREATMENT; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT THEREOF; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS; NANOTECHNOLOGY; NUCLEAR ENGINEERING; NUCLEAR PHYSICS; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICS; POWDER METALLURGY; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; SPIRITS; TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOTOTHERWISE PROVIDED FOR; TRANSPORTING; VINEGAR; WINE; WORKING METALLIC POWDER

The present invention relates to a pH sensitive particle, a method of preparation thereof, and a use thereof. More particularly, the invention provides a pH sensitive metal nanoparticle and its use for medical treatment utilizing cell necrosis during photothermal therapy. The pH sensitive metal nanoparticle based on this invention consists of a pH sensitive ligand compound whose charge changes depending on the pH of the metal nanoparticle. The particle can be collected in cells, such as cancer cells which present an abnormal pH environment. The pH sensitive metal nanoparticle based on this invention can induce cell death through a photothermal procedure after aggregation. Therefore, the invention enables medical treatment using cell necrosis for e.g. cancer treatment.