SINGLE-TIME VACCINES

• Main Authors: MARTIN OLIVER GERMAN PEREZ, GONZALEZ ELIZABETH AZNAR, GONZALEZ MIRIAM DE SAN JUAN BOSCO LASTRE, GUTIERREZ NIURYS NU?EZ, CUELLO MARIBEL PEREZ, CABRERA OSMIR BLANCO, ACEVEDO REINALDO GROGUES, ZAYAS CARIDAD VIGNIER, DEL CAMPO ALONSO JUDITH MONICA, ROMEU BELKIS ALVAREZ, GONZALEZ JULIO ANTONIO BALBOA
• Format: Patent
• Language: English
• Published: 20.10.2011
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention is related to the field of vaccines. The technical objective is to obtain novel unitemporal therapeutic and prophylactic vaccines (single time vaccination strategy) using simultaneously one or more mucosal doses and one parenteral dose where the use of potent mucosal adjuvants are essential, preferable the Cochleate (AFCo I, Adjuvant Finlay Cochleate 1). The incorporation or co-administration by parenteral and mucosal routes of non-related PL antigens (heterologous), and/or the additional use of delivery systems like Aluminum, Chitosan or oil/water emulsions by parenteral application is also included in this invention. The induction of cellular immune responses than including systemic specific IgG and secretory specific IgA is obtained with at least two simultaneously doses. So, this unitemporal strategy is applicable to obtaining new unique or multiples vaccines (several mucosal vaccine antigens with the corresponding parenteral combine vaccine) in the pharmaceutical industry which permit to increase vaccine coverage and reduce the time-cost of vaccine campaigns.