NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO

• Main Authors: FILVAROFF ELLEN, STALA JOY ANNE, MONTGOMERY CHARLES, IRVING BRYAN, VOGEL PETER, MASSEY ERIN MARIE, MCLAIN DINA REBECCA, HORNER ALLISON ANNE BYERS, FAN LIANGFEN, TOWNSEND TERESA GAIL, COMBS KATHERIN E, PHILLIPS HEIDI, JUNUTULA JAGATH REDDY, SHI ZHENG-ZHENG, MINZE LAURIE JEANETTE, RANGEL CAROLINA, SPARKS MARY JEAN, DE SAUVAGE FREDERIC, SEVAUX TRACY ELLEN WILLIS, PAYNE BOBBY JOE
• Format: Patent
• Language: English
• Published: 28.07.2011
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.