2,4-DIAMINOPYRIMIDINE COMPOUND

Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKC inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. The present inventors have conducted extensive studies on a compound having a P...

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Bibliographic Details
Main Authors CHIDA NOBORU, TANAKA AKIRA, NAGASHIMA SHINYA, MUKOYOSHI KOICHIRO, MAEDA JUN, KUNIKAWA SHIGEKI, TAKASUNA YUJI
Format Patent
LanguageEnglish
Published 30.06.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKC inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. The present inventors have conducted extensive studies on a compound having a PKC inhibition activity, and as a result, they have found that a compound having a structure such as aralkyl and the like on an amino group at the 2-position and also having a structure such as an adamantylalkyl group and the like on an amino group at the 4-position of 2,4-diaminopyrimidine, or a salt thereof has an excellent PKC inhibition activity, thereby completing the present invention. The 2,4-diaminopyrimidine compound of the present invention can be used as a PKC inhibitor or an inhibitor of acute rejection occurring in transplantation.
Bibliography:Application Number: US200913061311