Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof

The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and c...

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Main Authors MUIR MATTHEW STEWART, NEFFE AXEL THOMAS, LEE HANNAH YUN YOUNG, COXON JAMES MORRISS, JONES MATTHEW ALAN, STUART BLAIR GIBB, AITKEN STEVEN GEOFFREY, MCNABB STEPHEN BRIAN, ROBERTSON LUCINDA JANE GOODRICKE, DUNCAN JOANNA KIMBERLEY, MORTON JAMES DAVID, KLANCHANTRA MUTITA, ABELL ANDREW DAVID, NIKKEL JANNA MARIE, BICKERSTAFFE ROY
Format Patent
LanguageEnglish
Published 27.01.2011
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.
Bibliography:Application Number: US20070446053