PROCESS FOR PREPARING CRYSTALLINE CALCIUM MUPIROCIN DIHYDRATE

Provided herein are methods of preparing crystalline mupirocin calcium dihydrate comprising combining solid mupirocin, solid calcium carbonate, and water in an amount sufficient to form a heterogeneous mixture and precipitate crystalline mupirocin calcium dihydrate from the mixture. In some embodime...

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Bibliographic Details
Main Authors DEFTERDAROVIC NAFIS, CAVUZIC DRAZEN, TUDJA MARIJAN
Format Patent
LanguageEnglish
Published 20.01.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided herein are methods of preparing crystalline mupirocin calcium dihydrate comprising combining solid mupirocin, solid calcium carbonate, and water in an amount sufficient to form a heterogeneous mixture and precipitate crystalline mupirocin calcium dihydrate from the mixture. In some embodiments, the methods produce nanocrystalline mupirocin calcium dihydrate, suitable for use in pharmaceutical formulations.
Bibliography:Application Number: US20080863657