2'-CYANOPYRIMIDINE NUCLEOSIDE COMPOUND

The present invention provides a pyrimidine nucleoside compound represented by the following formula (1): [wherein one of X and Y is cyano and the other is hydrogen; and i) R1 is hydrogen, and R2 is alkyloxycarbonyl wherein the alkyl moiety is straight or branched C5-12 alkyl (the alkyl may be subst...

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Bibliographic Details
Main Author DOHI SUGURU
Format Patent
LanguageEnglish
Published 26.08.2010
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The present invention provides a pyrimidine nucleoside compound represented by the following formula (1): [wherein one of X and Y is cyano and the other is hydrogen; and i) R1 is hydrogen, and R2 is alkyloxycarbonyl wherein the alkyl moiety is straight or branched C5-12 alkyl (the alkyl may be substituted), or alternatively, ii) R1 is alkyloxycarbonyl wherein the alkyl moiety is straight or branched C9 alkyl or alkenyloxycarbonyl wherein the alkenyl moiety is straight or branched C9 alkenyl, and R2 is hydrogen] or a salt thereof. The pyrimidine nucleoside compound or a salt thereof of the present invention shows a higher antitumor effect than existing pyrimidine nucleoside compounds.
Bibliography:Application Number: US20070374075