CORONARY STENT WITH ASYMMETRIC DRUG RELEASING CONTROLLED COATING

• Main Authors: ZHANG HAIJUN, SHANG XIAOXIN, BEI JIANZHONG, WANG XIANGFEI, GE JUNBO, WANG SHENGUO, GUO HAIHONG
• Format: Patent
• Language: English
• Published: 01.07.2010
• Subjects: APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL; BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PERFORMING OPERATIONS; PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL; PROSTHESES; SPRAYING OR ATOMISING IN GENERAL; TRANSPORTING; TREATMENT OR PROTECTION OF EYES OR EARS

A coronary stent is provided with asymmetric drug releasing controlled coating used in interventional therapy of coronary disease, containing a bare stent and a coating consisting of drug and carrier, the coating is coated onto the outer wall surface of the bare stent, and is multi-layered. The drug concentration in the coating increases in sequence from the outer layer to the inner layer. The drugs used in different layers of the coating may be identical or different, and particularly may be one or more selected from taxol, rapamycin, heparin, docetaxel and a combination thereof. The carrier may be a random (lactide-glycolide) copolymer having a molecular weight of 50,000-200,000. The drug-coated stent of the present invention employs highly effective drugs, enabling a thinnest coating and reducing the vascular irritation. The drug release is regulated by altering the coating manner so as to satisfy the clinical requirement for controlled drug release. The employed asymmetric coating promotes regenerative repairing of vascular endothelium. The present invention is a drug-coated coronary stent with reasonable design, with the coating capable of effectively preventing vascular restenosis and reducing occurrence of late thrombosis.